RB1 monoclonal antibody, clone 172C1094
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis : HL-60 cells were treated with camptothecin for 24 hours.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of RB1. Using RB1 monoclonal antibody, clone 172C1094 (Cat # MAB0096) in sections of primary human breast tumors. Image courtesy of Dr. Macleod, The Ben May Institute for Cancer Research, The University of Chicago.
-
Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of RB1.
Immunogen
A synthetic peptide corresponding to the caspase-3-induced cleavage site of human RB1.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.05% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Cell lysate)
Western blot analysis : HL-60 cells were treated with camptothecin for 24 hours.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of RB1. Using RB1 monoclonal antibody, clone 172C1094 (Cat # MAB0096) in sections of primary human breast tumors. Image courtesy of Dr. Macleod, The Ben May Institute for Cancer Research, The University of Chicago. -
Gene Info — RB1
Entrez GeneID
5925Gene Name
RB1
Gene Alias
OSRC, RB, p105-Rb, pRb, pp110
Gene Description
retinoblastoma 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq
Other Designations
OTTHUMP00000018397|retinoblastoma suspectibility protein|retinoblastoma-associated protein
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer.
Huh JH, Kim TH, Kim K, Song JA, Jung YJ, Jeong JY, Lee MJ, Kim YK, Lee DH, An HJ.
British Journal of Cancer 2013 Jul; 109(2):452.
Application：WB-Tr, Human, SKOV3, SKP10, SKP16 cells.
-
A novel form of pRb expressed during normal myelopoiesis and in tumour-associated macrophages.
Liu HP, Thompson AM, Macleod KF.
Cell proliferation 2005 Jan; 38(1):13.
-
Dysregulation of miR-106a and miR-591 confers paclitaxel resistance to ovarian cancer.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com