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Last updated: 2023/3/26

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Anti-Denosumab (Human) ELISA Kit (Qualitative) 

  • Catalog # : KA6826
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  • Specification
  • Product Description:
  • Anti-Denosumab (Human) ELISA Kit (Qualitative) is a qualitative determination of antibodies to Denosumab in serum and plasma.
  • Reactivity:
  • Human
  • Storage Instruction:
  • Store the kit at 4°C.
  • Suitable Sample:
  • Serum or Plasma
  • Sample Volume:
  • 20 uL
  • Label:
  • HRP-conjugate
  • Absorbance (nm):
  • 450/650 nm
  • Detection Method:
  • Colorimetric
  • Assay Type:
  • Qualitative
  • Regulation Status:
  • For research use only (RUO)
  • Applications
  • Qualitative
  • Application Image
  • Qualitative
  • Gene Information
  • Entrez GeneID:
  • 8600
  • Gene Name:
  • TNFSF11
  • Gene Alias:
  • CD254,ODF,OPGL,OPTB2,RANKL,TRANCE,hRANKL2,sOdf
  • Gene Description:
  • tumor necrosis factor (ligand) superfamily, member 11
  • Gene Summary:
  • This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000178585,TNF-related activation-induced cytokine,osteoclast differentiation factor,osteoprotegerin ligand,receptor activator of nuclear factor kappa B ligand,tumor necrosis factor ligand superfamily, member 11
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