TTR (Human) ELISA Kit
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Specification
Product Description
TTR (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human TTR.
Suitable Sample
Cell Culture Samples, CSF, Milk, Plasma, Saliva, Serum, Urine
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
0.122 to 31.25 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — TTR
Entrez GeneID
7276Gene Name
TTR
Gene Alias
HsT2651, PALB, TBPA
Gene Description
transthyretin
Omim ID
176300Gene Ontology
HyperlinkGene Summary
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq
Other Designations
prealbumin, amyloidosis type I|thyroxine-binding prealbumin
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Interactome
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Disease
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Publication Reference
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A lower ratio of reduced to total albumin in serum is associated with protein nutritional status of pregnant women in Japan.
Fuka Tabata, Yasuaki Wada, Takuya Shibasaki, Satomi Kawakami, Mayumi Inubashiri, Masayoshi Hosaka, Kiwamu Noshiro, Takeshi Umazume, Kazuhiro Miyaji.
Nutrition Research (New York, N.Y.) 2023 Mar; 114:1.
Application:Quant, Human, Human serum.
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Ligand conjugate SAR and enhanced delivery in NHP.
Richard James Holland, Kieu Lam, Xin Ye, Alan D Martin, Mark C Wood, Lorne Palmer, David Fraser, Kevin McClintock, Sara Majeski, Agnes Jarosz, Amy C H Lee, Emily P Thi, Adam Judge, James Heyes.
Molecular Therapy 2021 Oct; 29(10):2910.
Application:Quant, Mouse, Mouse plasma.
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Effects of Parenteral Amino Acid Administration on the Postoperative Nutritional Status and Wound Healing of Protein-Malnourished Rats.
Wada A, Sonoda C, Makino Y, Hama Y, Nagahama A, Harada D.
Journal of Nutritional Science and Vitaminology 2018 Jan; 64:34.
Application:ELISA, Rat, Plasma.
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Transthyretin represses neovascularization in diabetic retinopathy.
Shao J, Yao Y.
Molecular Vision 2016 Oct; 22:1188.
Application:Quan, Human, Human retinal microvascular endothelial cells.
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Repression of retinal microvascular endothelial cells by transthyretin under simulated diabetic retinopathy conditions.
Shao J, Yao Y.
International Journal of Ophthalmology. 2016 Jun; 9(6):809.
Application:ELISA, Human, Retinal pigment epithelial cells.
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Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes.
Jing J, Isoherranen N, Robinson-Cohen C, Petrie I, Kestenbaum BR, Yeung CK.
Clinical and Translational Science 2016 Aug; 9(4):207.
Application:ELISA, Human, Plasma.
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CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci.
Mu Y, Jin S, Shen J, Sugano A, Takaoka Y, Qiang L, Imbimbo BP, Yamamura K, Li Z.
FEBS Letters 2015 Mar; 589(7):849.
Application:ELISA, Mouse, Serum.
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Terminal galactose residues on transferrin are increased in midlife adults compared to young adults.
Dunston CR, Choudhury K, Griffiths HR.
Proteomics 2012 Nov; 12(21):3147.
Application:Quant, Human, Human plasma.
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Prealbumin, mortality, and cause-specific hospitalization in hemodialysis patients.
Chertow GM, Goldstein-Fuchs DJ, Lazarus JM, Kaysen GA.
Kidney International 2005 Dec; 68(6):2794.
Application:Quant, Human, Serum from hemodialysis patients.
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Prealbumin: a marker for nutritional evaluation.
Beck FK, Rosenthal TC.
American Family Physician 2002 Apr; 65(8):1575.
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Transthyretin: a review from a structural perspective.
Hamilton JA, Benson MD.
Cellular and Molecular Life Sciences 2001 Sep; 58(10):1491.
Application:Quant, Human, Human cerebrospinal fluid.
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A lower ratio of reduced to total albumin in serum is associated with protein nutritional status of pregnant women in Japan.
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