The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations:
EF-hand calcium binding protein 3,Nek2-interacting protein 1,OTTHUMP00000030659,OTTHUMP00000035342,X11L-binding protein 51,amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein,neuronal calcium-binding protein NECAB3,synaptotagmi