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Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

GIT2

Gene Alias

CAT-2, DKFZp686G01261, KIAA0148, MGC760

Gene Description

G protein-coupled receptor kinase interacting ArfGAP 2

Omim ID

Gene Ontology

Gene Summary

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq

Other Designations

ARF GTPase-activating protein GIT2|G protein-coupled receptor kinase interactor 2|GRK-interacting protein 2|cool-associated, tyrosine phosphorylated protein 2