CXCR4 monoclonal antibody (M02), clone 1F8
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More Files
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Western Blot (Tissue lysate)
CXCR4 monoclonal antibody (M02), clone 1F8. Western Blot analysis of CXCR4 expression in human Intestinal wall.
Western Blot detection against Immunogen (30.8 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant CXCR4.
Immunogen
CXCR4 (AAH20968, 1 a.a. ~ 46 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYS
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (30.8 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
CXCR4 monoclonal antibody (M02), clone 1F8. Western Blot analysis of CXCR4 expression in human Intestinal wall.Western Blot (Recombinant protein)
ELISA
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Gene Info — CXCR4
Entrez GeneID
7852GeneBank Accession#
BC020968Protein Accession#
AAH20968Gene Name
CXCR4
Gene Alias
CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
Gene Description
chemokine (C-X-C motif) receptor 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
C-X-C chemokine receptor type 4|CD184 antigen|chemokine (C-X-C motif), receptor 4 (fusin)|chemokine receptor 4|fusin|leukocyte-derived seven-transmembrane-domain receptor|lipopolysaccharide-associated protein 3|neuropeptide Y receptor Y3|seven transmembra
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Interactome
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Pathway
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Disease
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Publication Reference
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LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy.
Capitani N, Lori G, Paoli P, Patrussi L, Troilo A, Baldari CT, Raugei G, D'Elios MM.
Cancer Cell International 2019 Mar; 19:67.
Application：Flow Cyt, Human, Mec-1 cells.
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Negative regulation of chemokine receptor signaling and B-cell chemotaxis by p66Shc.
Patrussi L, Capitani N, Cannizzaro E, Finetti F, Lucherini OM, Pelicci PG, Baldari CT.
Cell Death & Disease 2014 Feb; 5:e1068.
Application：WB-Tr, Human, MEC-1 cells.
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LMW-PTP targeting potentiates the effects of drugs used in chronic lymphocytic leukemia therapy.
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