TYROBP DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human TYROBP DNA using DNAx™ Immune technology.
Technology
Immunogen
TYROBP (NP_003323.1, 22 a.a. ~ 113 a.a) full-length human DNA
Sequence
LRPVQAQAQSDCSCSTVSPGVLAGIVMGDLVLTVLIALAVYFLGRLVPRGRGAAEAATRKQRITETESPYQELQGQRSDVYSDLNTQRPYYK
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of TYROBP expression in transfected 293T cell line by TYROBP DNAxPab polyclonal antibody.
Lane 1: TYROBP transfected lysate(31.24 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — TYROBP
Entrez GeneID
7305GeneBank Accession#
NM_003332.2Protein Accession#
NP_003323.1Gene Name
TYROBP
Gene Alias
DAP12, KARAP, PLOSL
Gene Description
TYRO protein tyrosine kinase binding protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Two alternative transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described, but their full-length nature has not been deterimined. [provided by RefSeq
Other Designations
DNAX-activation protein 12|killer activating receptor associated protein
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Interactome
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Disease
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