PSMC4 MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PSMC4 protein.
Immunogen
PSMC4 (NP_006494, 1 a.a. ~ 418 a.a) full-length human protein.
Sequence
MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PSMC4 expression in transfected 293T cell line (H00005704-T01) by PSMC4 MaxPab polyclonal antibody.
Lane 1: PSMC4 transfected lysate(45.98 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — PSMC4
Entrez GeneID
5704GeneBank Accession#
NM_006503Protein Accession#
NP_006494Gene Name
PSMC4
Gene Alias
MGC13687, MGC23214, MGC8570, MIP224, S6, TBP7
Gene Description
proteasome (prosome, macropain) 26S subunit, ATPase, 4
Omim ID
602707Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
MB67 interacting protein|Tat-binding protein 7|protease 26S subunit 6|proteasome 26S ATPase subunit 4
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Interactome
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Pathway
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