HLA-DQA1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HLA-DQA1 full-length
Host
Human
Theoretical MW (kDa)
28
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HLA-DQA1 antibody (H00003117-D01P) by Western Blots.
SDS-PAGE Gel
HLA-DQA1 transfected lysate.
Western Blot
Lane 1: HLA-DQA1 transfected lysate ( 28.00 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HLA-DQA1
Entrez GeneID
3117GeneBank Accession#
NM_002122Protein Accession#
NP_002113.2Gene Name
HLA-DQA1
Gene Alias
CD, CELIAC1, DQ-A1, FLJ27088, FLJ27328, GSE, HLA-DQA, MGC149527
Gene Description
major histocompatibility complex, class II, DQ alpha 1
Gene Ontology
HyperlinkGene Summary
HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq
Other Designations
Gluten-sensitive enteropathy (celiac disease)|MHC HLA-DQ alpha|MHC class II HLA-D alpha glycoprotein|MHC class II HLA-DQ-alpha-1|MHC class II antigen|MHC class II surface glycoprotein|OTTHUMP00000029141|OTTHUMP00000176885|OTTHUMP00000178551|OTTHUMP0000017
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Interactome
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Pathway
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Disease
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