HLA-DPB1 monoclonal antibody (M01), clone 6C6
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of HLA-DPB1 expression in transfected 293T cell line by HLA-DPB1 monoclonal antibody (M01), clone 6C6.
Lane 1: HLA-DPB1 transfected lysate(29 KDa).
Lane 2: Non-transfected lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to HLA-DPB1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 0.5 ug/ml]
Immunoprecipitation
Immunoprecipitation of HLA-DPB1 transfected lysate using anti-HLA-DPB1 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with HLA-DPB1 monoclonal antibody.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged HLA-DPB1 is 10 ng/ml as a capture antibody.
Western Blot detection against Immunogen (54.12 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant HLA-DPB1.
Immunogen
HLA-DPB1 (AAH13184, 1 a.a. ~ 258 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYVYQGRQECYAFNGTQRFLERYIYNREEYARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRAVPDRVCRHNYELDEAVTLQRRVQPKVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYICQVEHTSLDSPVTVEWKAQSDSAQSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (54.12 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of HLA-DPB1 expression in transfected 293T cell line by HLA-DPB1 monoclonal antibody (M01), clone 6C6.
Lane 1: HLA-DPB1 transfected lysate(29 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to HLA-DPB1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 0.5 ug/ml]Immunoprecipitation
Immunoprecipitation of HLA-DPB1 transfected lysate using anti-HLA-DPB1 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with HLA-DPB1 monoclonal antibody.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged HLA-DPB1 is 10 ng/ml as a capture antibody.ELISA
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Gene Info — HLA-DPB1
Entrez GeneID
3115GeneBank Accession#
BC013184Protein Accession#
AAH13184Gene Name
HLA-DPB1
Gene Alias
DPB1, HLA-DP1B
Gene Description
major histocompatibility complex, class II, DP beta 1
Omim ID
142858Gene Ontology
HyperlinkGene Summary
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq
Other Designations
HLA DP14-beta chain|HLA-DP histocompatibility type, beta-1 subunit|MHC HLA DPB1|MHC class II HLA-DP-beta|MHC class II HLA-DP-beta-1|MHC class II HLA-DRB1|MHC class II antigen DP beta 1 chain|MHC class II antigen DPbeta1|MHC class II antigen beta chain|OTT
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Interactome
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Pathway
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Disease
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