FHIT monoclonal antibody (M03), clone 1E3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant FHIT.
Immunogen
FHIT (AAH32336, 31 a.a. ~ 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VVPGHVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFPASWR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (87); Rat (85)
Isotype
IgG1 kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
FHIT monoclonal antibody (M01), clone 1E3 Western Blot analysis of FHIT expression in HL-60 ( Cat # L014V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged FHIT is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — FHIT
Entrez GeneID
2272GeneBank Accession#
BC032336Protein Accession#
AAH32336Gene Name
FHIT
Gene Alias
AP3Aase, FRA3B
Gene Description
fragile histidine triad gene
Omim ID
601153Gene Ontology
HyperlinkGene Summary
This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. [provided by RefSeq
Other Designations
AP3A hydrolase|bis(5'-adenosyl)-triphosphatase|diadenosine 5',5'''-P1,P3-triphosphate hydrolase|dinucleosidetriphosphatase|tumor suppressor protein
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Interactome
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Pathway
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Disease
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