Products

Western Blot (Cell lysate)

DUSP9 monoclonal antibody (M04), clone 2E3 Western Blot analysis of DUSP9 expression in HeLa ( Cat # L013V1 ).

Western Blot (Recombinant protein)

ELISA

In situ Proximity Ligation Assay (Cell)

Proximity Ligation Analysis of protein-protein interactions between MAPK3 and DUSP9. HeLa cells were stained with anti-MAPK3 rabbit purified polyclonal 1:1200 and anti-DUSP9 mouse monoclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).

Entrez GeneID

1852

GeneBank Accession#

NM_001395

Protein Accession#

NP_001386

Gene Name

DUSP9

Gene Alias

MKP-4, MKP4

Gene Description

dual specificity phosphatase 9

Omim ID

300134

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq

Other Designations

OTTHUMP00000025951|OTTHUMP00000025953|map kinase phosphatase 4|serine/threonine specific protein phosphatase