DNASE1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of DNASE1 expression in transfected 293T cell line (H00001773-T01) by DNASE1 MaxPab polyclonal antibody.
Lane 1: DNASE1 transfected lysate(31.02 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human DNASE1 protein.
Immunogen
DNASE1 (NP_005214, 1 a.a. ~ 282 a.a) full-length human protein.
Sequence
MRGMKLLGALLALAALLQGAVSLKIAAFNIQTFGETKMSNATLVSYIVQILSRYDIALVQEVRDSHLTAVGKLLDNLNQDAPDTYHYVVSEPLGRNSYKERYLFVYRPDQVSAVDSYYYDDGCEPCGNDTFNREPAIVRFFSRFTEVREFAIVPLHAAPGDAVAEIDALYDVYLDVQEKWGLEDVMLMGDFNAGCSYVRPSQWSSIRLWTSPTFQWLIPDSADTTATPTHCAYDRIVVAGMLLRGAVVPDSALPFNFQAAYGLSDQLAQAISDHYPVEVMLK
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DNASE1 expression in transfected 293T cell line (H00001773-T01) by DNASE1 MaxPab polyclonal antibody.
Lane 1: DNASE1 transfected lysate(31.02 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — DNASE1
Entrez GeneID
1773GeneBank Accession#
NM_005223Protein Accession#
NP_005214Gene Name
DNASE1
Gene Alias
DKFZp686H0155, DNL1, DRNI, FLJ38093, FLJ44902
Gene Description
deoxyribonuclease I
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq
Other Designations
DNase I, lysosomal|Dornase alfa|human urine deoxyribonuclease I
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Interactome
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Disease
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