CREB1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human CREB1 full-length ORF ( AAH10636, 1 a.a. - 341 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNHVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
63.25
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CREB1
Entrez GeneID
1385GeneBank Accession#
BC010636Protein Accession#
AAH10636Gene Name
CREB1
Gene Alias
CREB, MGC9284
Gene Description
cAMP responsive element binding protein 1
Omim ID
123810Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
active transcription factor CREB|cAMP-response element-binding protein-1|transactivator protein
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Interactome
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Pathway
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Disease
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Publication Reference
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ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells.
Du H, Le Y, Sun F, Li K, Xu Y.
Analytical Cellular Pathology (Amsterdam) 2019 Feb; 2019:1575031.
Application:IP, Human, Bel-7402, SMMC-7721 cells.
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Organic conjugated small molecule materials based optical probe for rapid, colorimetric and UV-vis spectral detection of phosphorylated protein in placental tissue.
Wang Y, Yang N, Liu Y.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy 2018 Jan; 194:45.
Application:ELISA, Recombinant protein.
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Detection of CREB Phosphorylation via Zr (IV) Ion Mediated Signal Amplification.
Yin T, Li H, Yang N, Gao T, Sun L, Li G.
Biosensors & Bioelectronics 2014 Jun; 56:1.
Application:Func, DNA.
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ILF2 Directly Binds and Stabilizes CREB to Stimulate Malignant Phenotypes of Liver Cancer Cells.
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