CBFB purified MaxPab mouse polyclonal antibody (B01P)
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human CBFB protein.
Immunogen
CBFB (NP_074036.1, 1 a.a. ~ 187 a.a) full-length human protein.
Sequence
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEARRQQDPSPGSNLGGGDDLKLR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (99); Rat (97)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CBFB expression in transfected 293T cell line (H00000865-T01) by CBFB MaxPab polyclonal antibody.
Lane 1: CBFB transfected lysate(20.57 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — CBFB
Entrez GeneID
865GeneBank Accession#
NM_022845.2Protein Accession#
NP_074036.1Gene Name
CBFB
Gene Alias
PEBP2B
Gene Description
core-binding factor, beta subunit
Omim ID
121360Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
SL3-3 enhancer factor 1 beta subunit|SL3/AKV core-binding factor beta subunit|polyomavirus enhancer binding protein 2, beta subunit
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