CCND1 purified MaxPab mouse polyclonal antibody (B02P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of CCND1 expression in transfected 293T cell line (H00000595-T03) by CCND1 MaxPab polyclonal antibody.
Lane 1: CCND1 transfected lysate(33.70 KDa).
Lane 2: Non-transfected lysate.
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between CDK4 and CCND1. HeLa cells were stained with anti-CDK4 rabbit purified polyclonal 1:1200 and anti-CCND1 mouse purified polyclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to CCND1 on HeLa cell. [antibody concentration 30 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human CCND1 protein.
Immunogen
CCND1 (AAH23620.1, 1 a.a. ~ 295 a.a) full-length human protein.
Sequence
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CCND1 expression in transfected 293T cell line (H00000595-T03) by CCND1 MaxPab polyclonal antibody.
Lane 1: CCND1 transfected lysate(33.70 KDa).
Lane 2: Non-transfected lysate.
In situ Proximity Ligation Assay (Cell)
Proximity Ligation Analysis of protein-protein interactions between CDK4 and CCND1. HeLa cells were stained with anti-CDK4 rabbit purified polyclonal 1:1200 and anti-CCND1 mouse purified polyclonal antibody 1:50. Each red dot represents the detection of protein-protein interaction complex, and nuclei were counterstained with DAPI (blue).Immunofluorescence
Immunofluorescence of purified MaxPab antibody to CCND1 on HeLa cell. [antibody concentration 30 ug/ml] -
Gene Info — CCND1
Entrez GeneID
595GeneBank Accession#
NM_053056Protein Accession#
AAH23620.1Gene Name
CCND1
Gene Alias
BCL1, D11S287E, PRAD1, U21B31
Gene Description
cyclin D1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
Other Designations
B-cell CLL/lymphoma 1|G1/S-specific cyclin D1
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Interactome
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Pathway
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Disease
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Publication Reference
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Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation.
Rangrez AY, Pott J, Kluge A, Frauen R, Stiebeling K, Hoppe P, Sossalla S, Frey N, Frank D.
Biochimica et Biophysica Acta 2017 Jan; 1864(4):634.
Application：WB, Rat, Neonatal rat cardiomyocytes (NRVCMs).
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Myeloid leukemia factor-1 is a novel modulator of neonatal rat cardiomyocyte proliferation.
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