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Western Blot (Transfected lysate)

Western Blot analysis of ATP6V0B expression in transfected 293T cell line (H00000533-T04) by ATP6V0B MaxPab polyclonal antibody.

Lane 1: ATP6V0B transfected lysate(21.40 KDa).
Lane 2: Non-transfected lysate.

Entrez GeneID

533

GeneBank Accession#

NM_004047.3

Protein Accession#

NP_004038.1

Gene Name

ATP6V0B

Gene Alias

ATP6F, HATPL, VMA16

Gene Description

ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b

Omim ID

603717

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the transmembrane V0 domain and is the human counterpart of yeast VMA16. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq

Other Designations

ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21kD|ATPase, H+ transporting, lysosomal 21kDa, V0 subunit c''|H(+)-transporting two-sector ATPase, subunit F|OTTHUMP00000010012|V-ATPase subunit c''|vacuolar ATP synthase 21 kDa proteolipid subunit