AGT purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human AGT protein.
Immunogen
AGT (AAH11519.1, 1 a.a. ~ 485 a.a) full-length human protein.
Sequence
MRKRAPQSEMAPAGVSLRATILCLLAWAGLAAGDRVYIHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQLVLVAAKLDTEDKLRAAMVGMLANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLTGASVDSTLAFNTYVHFQGKMKGFSLLAEPQEFWVDNSTSVSVPMLSGMGTFQHWSDIQDNFSVTQVSFTESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAILHTELNLQKLSNDRIRVGEVLNSIFFELEADEREPTESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANPLSTA
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Rat (64)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
AGT MaxPab rabbit polyclonal antibody. Western Blot analysis of AGT expression in human pancreas.Western Blot (Transfected lysate)
Western Blot analysis of AGT expression in transfected 293T cell line (H00000183-T01) by AGT MaxPab polyclonal antibody.
Lane 1: AGT transfected lysate(53.10 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — AGT
Entrez GeneID
183GeneBank Accession#
BC011519Protein Accession#
AAH11519.1Gene Name
AGT
Gene Alias
ANHU, FLJ92595, FLJ97926, SERPINA8
Gene Description
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq
Other Designations
OTTHUMP00000035878|alpha-1 antiproteinase, antitrypsin|angiotensin I|angiotensin II|angiotensinogen|pre-angiotensinogen|serine (or cysteine) proteinase inhibitor
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Interactome
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Pathway
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Disease
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