FUS Split FISH Probe
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human pancreatic cancer (FFPE) stained with FUS Split FISH Probe. Human pancreatic cancer showed no FUS gene split.
Hybridization position of the probes on the chromosome:
Hybridization position of the probes on the chromosome:
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Specification
Product Description
Labeled FISH probes for identification of gene split using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: FUS(Texas Red)
Size: Approximately 620kb
Fluorophore: Texas Red
Location: 16p11.2Probe 2
Name: FUS(FITC)
Size: Approximately 410kb
Fluorophore: FITC
Location: 16p11.2Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome:
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Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human pancreatic cancer (FFPE) stained with FUS Split FISH Probe. Human pancreatic cancer showed no FUS gene split. -
Gene Info — FUS
Entrez GeneID
2521Gene Name
FUS
Gene Alias
CHOP, FUS-CHOP, FUS1, TLS, TLS/CHOP, hnRNP-P2
Gene Description
fusion (involved in t(12;16) in malignant liposarcoma)
Omim ID
137070Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq
Other Designations
FUS-CHOP fusion protein|FUS-CHOP protein fusion|Fusion gene in myxoid liposarcoma|fus-like protein|fus/tls-chop oncogene|heterogeneous nuclear ribonucleoprotein P2|translocated in liposarcoma
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Interactome
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Disease
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