Last updated: 2023/3/19

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Anti-ACTN4 monoclonal antibody

Product Description:
Anti-ACTN4 is a useful marker in molecular phenotyping of tumors such as non-small cell lung cancer, pancreatic and ovarian cancers.

1.
Prognostic significance of gene amplification of ACTN4 in stage I and II oral tongue cancer.
Kakuya T, Mori T, Yoshimoto S, Watabe Y, Miura N, Shoji H, Onidani K, Shibahara T, Honda K.Int J Oral Maxillofac Surg. 2017 Apr 3. [Epub ahead of print]

2.
Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4.
Nami Miura, Masahiro Kamita, Takanori Kakuya, Yutaka Fujiwara, Koji Tsuta, Hideaki Shiraishi, Fumitaka Takeshita, Takahiro Ochiya, Hirokazu Shoji, Wilber Huang, Yuichiro Ohe, Tesshi Yamada, Kazufumi Honda.Oncotarget. 2016 April 21.

3.
Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification.
Noro R, Honda K, Tsuta K, Ishii G, Maeshima AM, Miura N, Furuta K, Shibata T, Tsuda H, Ochiai A, Sakuma T, Nishijima N, Gemma A, Asamura H, Nagai K, Yamada T.Ann Oncol. 2013 Jul 30.

4.
Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance.
Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, Imoto I, Inazawa J, Yamada T, Matsubara O.Mod Pathol. 2009 Apr;22(4):499-507. Epub 2009 Jan 16.

5.
Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas.
Kikuchi S, Honda K, Tsuda H, Hiraoka N, Imoto I, Kosuge T, Umaki T, Onozato K, Shitashige M, Yamaguchi U, Ono M, Tsuchida A, Aoki T, Inazawa J, Hirohashi S, Yamada T.Clin Cancer Res. 2008 Sep 1;14(17):5348-56.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Immunoperoxidase of monoclonal antibody to ACTN4 on formalin-fixed paraffin-embedded human lung adenocarcinoma. [antibody concentration 1.5 ug/ml]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Immunoperoxidase of monoclonal antibody to ACTN4 on formalin-fixed paraffin-embedded human ovarian cancer. [antibody concentration 1.5 ug/ml]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
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Immunoperoxidase of monoclonal antibody to ACTN4 on formalin-fixed paraffin-embedded human pancreatic cancer. [antibody concentration 1.5 ug/ml]

Gene Summary:
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq