Rabbit polyclonal antibody raised against synthetic peptide of ILK.
A synthetic peptide corresponding to C-terminus of human ILK.
Theoretical MW (kDa):
Human, Mouse, Rat
This antibody recognizes 59 KDa of ILK1.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Western Blot (0.5-4 ug/mL) Immunohistochemistry (Frozen sections) (10-20 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10-20 ug/mL) The optimal working dilution should be determined by the end user.
In PBS (30% glycerol, 0.5% BSA, 0.01% thimerosal)
Store at -20°C. For long term storage store at -80°C. Aliquot to avoid repeated freezing and thawing.
This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq