Rabbit polyclonal antibody raised against synthetic peptide of CYP19A1.
A synthetic peptide corresponding to residues surrounding amino acids 385 of human CYP19A1.
Theoretical MW (kDa):
Bovine, Chicken, Horse, Human, Mouse, Pig, Rabbit, Rat, Sheep
This antibody should recognize aromatase in samples from human, mouse, rat, bovine, porcine, pig, sheep, rabbit, horse and chicken origins. A 55 KDa band can be detected, corresponding to the expected molecular weight of Aromatase. An additional 35 KDa band (believe to be the cleavage product of Aromatase) can also be detected in Jurkat cells.
Quality Control Testing:
Antibody Reactive Against Synthetic Peptide.
Western Blot (0.5-4 ug/mL) Immunohistochemistry (10-20 ug/mL) The optimal working dilution should be determined by the end user.
In PBS (30% glycerol, 0.5% BSA, 0.01% thimerosal)
Store at -20°C. For long term storage store at -80°C. Aliquot to avoid repeated freezing and thawing.
This product contains thimerosal: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq
OTTHUMP00000162543,aromatase,cytochrome P450, family 19,cytochrome P450, subfamily XIX (aromatization of androgens),estrogen synthetase,flavoprotein-linked monooxygenase,microsomal monooxygenase