UCP1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of UCP1.
Immunogen
A synthetic peptide corresponding to human UCP1.
Sequence
C-EQLKRELSKSRQ
Host
Goat
Theoretical MW (kDa)
33
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:128000)
Western Blot (0.1-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
UCP1 polyclonal antibody (Cat # PAB6905) (1 ug/mL) staining of human adipose lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — UCP1
Entrez GeneID
7350Protein Accession#
NP_068605.1Gene Name
UCP1
Gene Alias
SLC25A7, UCP
Gene Description
uncoupling protein 1 (mitochondrial, proton carrier)
Gene Ontology
HyperlinkGene Summary
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq
Other Designations
mitochondrial brown fat uncoupling protein|thermogenin|uncoupling protein 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.
Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, Uno K, Hasegawa Y, Gao J, Ishihara H, Shimosegawa T, Sakoda H, Asano T, Oka Y.
Diabetes 2005 Feb; 54(2):322.
Application:WB-Ti, Mouse, Liver.
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Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity.
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