IRAK4 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of IRAK4.
Immunogen
A synthetic peptide corresponding to human IRAK4.
Sequence
NKPITPSTYVRC
Host
Goat
Theoretical MW (kDa)
51.5
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
IRAK4 polyclonal antibody (Cat # PAB6731) (1 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRAK4
Entrez GeneID
51135Protein Accession#
NP_057207.1Gene Name
IRAK4
Gene Alias
IPD1, NY-REN-64, REN64
Gene Description
interleukin-1 receptor-associated kinase 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq
Other Designations
IRAK-4 mutated form 1|interleukin-1 receptor associated kinase 4
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Interactome
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Pathway
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Disease
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Publication Reference
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The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling.
Lye E, Mirtsos C, Suzuki N, Suzuki S, Yeh WC.
The Journal of Biological Chemistry 2004 Sep; 279(39):40653.
Application:WB, Mouse, MEFs.
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The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling.
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