ABCC4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
ABCC4 polyclonal antibody (Cat # PAB6698) staining (0.5 ug/mL) of rat renal cortex membranes (20 ug total protein per lane). Detected by western blot using chemiluminescence. Data kindly provided by Dr. Antje Steinbach, Ernst-Moritz-Arndt University of Greifswald.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ABCC4 polyclonal antibody (Cat # PAB6698) (4 ug/mL) staining of paraffin embedded human prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ABCC4.
Immunogen
A synthetic peptide corresponding to C-terminus of human ABCC4.
Sequence
CNGQPSTLTIFETAL
Host
Goat
Theoretical MW (kDa)
149, 150
Reactivity
Human, Rat
Specificity
This antibody is expected to recognize isoform 1 (NP_005836.2) only.
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (1-3 ug/mL)
Immunohistochemistry (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
ABCC4 polyclonal antibody (Cat # PAB6698) staining (0.5 ug/mL) of rat renal cortex membranes (20 ug total protein per lane). Detected by western blot using chemiluminescence. Data kindly provided by Dr. Antje Steinbach, Ernst-Moritz-Arndt University of Greifswald.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
ABCC4 polyclonal antibody (Cat # PAB6698) (4 ug/mL) staining of paraffin embedded human prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Immunocytochemistry
Immunofluorescence
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ABCC4
Entrez GeneID
10257Protein Accession#
NP_005836.2Gene Name
ABCC4
Gene Alias
EST170205, MOAT-B, MOATB, MRP4
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Omim ID
605250Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 4|OTTHUMP00000018560|bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)|canalicular multispecific organic anion transporter (ABC superfamily)|multidrug resistance-associated protein 4|multispecif
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Interactome
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Pathway
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Disease
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Publication Reference
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Essential role of vesicular nucleotide transporter in vesicular storage and release of nucleotides in platelets.
Hiasa M, Togawa N, Miyaji T, Omote H, Yamamoto A, Moriyama Y.
Physiological Reports 2014 Jun; 2(6):e12034.
Application：WB-Tr, Human, MEG-01 cells.
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MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.
Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A, Fridland A.
Nature Medicine 1999 Sep; 5(9):1048.
Application：WB, Bacteria, Human, BL21 bacteria, Human T-lymphoid cell line CEM-r1.
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Essential role of vesicular nucleotide transporter in vesicular storage and release of nucleotides in platelets.
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