ARAP3 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of ARAP3.
Immunogen
A synthetic peptide corresponding to human ARAP3.
Sequence
CTSSPPSSQPLT
Host
Goat
Theoretical MW (kDa)
170
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:4000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — ARAP3
Entrez GeneID
64411Protein Accession#
NP_071926Gene Name
ARAP3
Gene Alias
CENTD3, DRAG1, FLJ21065
Gene Description
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Omim ID
606647Gene Ontology
HyperlinkGene Summary
This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq
Other Designations
ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3|Arf and Rho GAP adapter protein 3|PtdIns(3,4,5)P3-binding protein|centaurin, delta 3|phosphoinositide binding protein
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Interactome
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Pathway
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Publication Reference
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Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT.
Molecular Cell 2002 Jan; 9(1):95.
Application:WB-Ti, Pig, Leukocytes, Pig tissues, Spleens.
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Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
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