AIRE polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
AIRE polyclonal antibody (Cat # PAB6198) staining (0.01 ug/mL) of HEK293 cell lysate untransfected (lane 1) and transfected with human AIRE (lane 2) .
Data kindly provided by Prof. Part Peterson, University of Tartu, Estonia.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
AIRE polyclonal antibody (Cat # PAB6198) staining (2.5 ug/mL) of paraffin embedded human thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of AIRE.
Immunogen
A synthetic peptide corresponding to human AIRE.
Sequence
C-QSMARPAAPFPS
Host
Goat
Theoretical MW (kDa)
57.7, 36.5
Reactivity
Human
Specificity
This antibody is expected to recognize isoforms 1 and 2 (NP_000374.1 and NP_000649.1 respecively).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:32000)
Western Blot (0.01-0.03 ug/mL)
Immunohistochemistry (2.5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
ChIP
Western Blot (Transfected lysate)
AIRE polyclonal antibody (Cat # PAB6198) staining (0.01 ug/mL) of HEK293 cell lysate untransfected (lane 1) and transfected with human AIRE (lane 2) .
Data kindly provided by Prof. Part Peterson, University of Tartu, Estonia.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
AIRE polyclonal antibody (Cat # PAB6198) staining (2.5 ug/mL) of paraffin embedded human thymus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AIRE
Entrez GeneID
326Protein Accession#
NP_000374.1;NP_000649.1Gene Name
AIRE
Gene Alias
AIRE1, APECED, APS1, APSI, PGA1
Gene Description
autoimmune regulator
Gene Ontology
HyperlinkGene Summary
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). [provided by RefSeq
Other Designations
autoimmune polyendocrinopathy candidiasis ectodermal dystrophy
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Interactome
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Pathway
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Disease
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Publication Reference
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The autoimmune regulator (AIRE) is a DNA-binding protein.
Kumar PG, Laloraya M, Wang CY, Ruan QG, Davoodi-Semiromi A, Kao KJ, She JX.
J Biol Chem 2001 Aug; 276(44):41357.
Application：IP, KA, WB, Mouse, Mouse thymus, Recombinant proteins.
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The autoimmune regulator (AIRE) is a DNA-binding protein.
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