ALPL polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ALPL.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ALPL.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein A purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of ALPL polyclonal antibody (Cat # PAB3138) in mouse brain tissue lysates (35 ug/lane). ALPL (arrow) was detected using the purified polyclonal antibody. -
Gene Info — ALPL
Entrez GeneID
249Protein Accession#
NP_000469;P05186Gene Name
ALPL
Gene Alias
AP-TNAP, FLJ40094, FLJ93059, HOPS, MGC161443, MGC167935, TNAP, TNSALP
Gene Description
alkaline phosphatase, liver/bone/kidney
Gene Ontology
HyperlinkGene Summary
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000002971|OTTHUMP00000002972|alkaline phosphatase, tissue-nonspecific isozyme|alkaline phosphomonoesterase|glycerophosphatase|liver/bone/kidney-type alkaline phosphatase|tissue non-specific alkaline phosphatase|tissue-nonspecific ALP
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Interactome
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Pathway
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Disease
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Publication Reference
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Neuropeptide Y and markers of osteoblast activity in dialysis patients: a cross-sectional study.
Panuccio V, Cutrupi S, Pizzini P, Mallamaci F, Tripepi G, Zoccali C.
American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation 2007 Dec; 50(6):1001.
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Delayed transport of tissue-nonspecific alkaline phosphatase with missense mutations causing hypophosphatasia.
Brun-Heath I, Lia-Baldini AS, Maillard S, Taillandier A, Utsch B, Nunes ME, Serre JL, Mornet E.
European Journal of Medical Genetics 2007 Sep; 50(5):367.
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Inhibition of alkaline phosphatase by cysteine: implications for calcium pyrophosphate dihydrate crystal deposition disease.
So PP, Tsui FW, Vieth R, Tupy JH, Pritzker KP.
The Journal of Rheumatology 2007 Jun; 34(6):1313.
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Neuropeptide Y and markers of osteoblast activity in dialysis patients: a cross-sectional study.
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