APOE polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APOE.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human APOE.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot analysis of APOE (arrow) using rabbit APOE polyclonal antibody (Cat # PAB2987). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the APOE gene (Lane 2) (Origene Technologies).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human hepatocarcinomareacted with APOE polyclonal antibody (Cat # PAB2987), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. -
Gene Info — APOE
Entrez GeneID
348Protein Accession#
NP_000032;P02649Gene Name
APOE
Gene Alias
AD2, LPG, MGC1571, apoprotein
Gene Description
apolipoprotein E
Gene Ontology
HyperlinkGene Summary
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq
Other Designations
apolipoprotein E3
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Interactome
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Disease
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Publication Reference
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Permissiveness of human hepatocellular carcinoma cell lines for hepatitis C virus entry and replication.
Coto-Llerena M, Koutsoudakis G, Boix L, López-Oliva JM, Caro N, Fernández-Carrillo C, González P, Gastaminza P, Bruix J, Forns X, Pérez-Del-Pulgar S.
Virus Research 2017 Jul; 240:35.
Application:WB-Ce, Human, BCLC5-C8.1, Huh7 cells.
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Interactions between hepatic lipase and apolipoprotein E gene polymorphisms affect serum lipid profiles of healthy Canadian adults.
Wood KC, Fullerton MD, El-Sohemy A, Bakovic M.
Applied Physiology, Nutrition, and Metabolism 2008 Aug; 33(4):761.
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The relationship between ApoE, TNFA, IL1a, IL1b and IL12b genes and HIV-1-associated dementia.
Pemberton LA, Stone E, Price P, van Bockxmeer F, Brew BJ.
HIV Medicine 2008 Oct; 9(8):677.
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The association of APOE genotype and cognitive decline in interaction with risk factors in a 65-69 year old community sample.
Christensen H, Batterham PJ, Mackinnon AJ, Jorm AF, Mack HA, Mather KA, Anstey KJ, Sachdev PS, Easteal S.
BMC Geriatrics 2008 Jul; 8:14.
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Permissiveness of human hepatocellular carcinoma cell lines for hepatitis C virus entry and replication.
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