AURKB polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
The AURKB polyclonal antibody (Cat # PAB2807) is used in Western blot to detect AURKB in mouse spleen tissue lysate.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with AURKB polyclonal antibody (Cat # PAB2807) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AURKB.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human AURKB.
Host
Rabbit
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
The AURKB polyclonal antibody (Cat # PAB2807) is used in Western blot to detect AURKB in mouse spleen tissue lysate.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Formalin-fixed and paraffin-embedded human cancer tissue reacted with AURKB polyclonal antibody (Cat # PAB2807) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma. -
Gene Info — AURKB
Entrez GeneID
9212Protein Accession#
NP_004208;Q96GD4Gene Name
AURKB
Gene Alias
AIK2, AIM-1, AIM1, ARK2, AurB, IPL1, STK12, STK5
Gene Description
aurora kinase B
Omim ID
604970Gene Ontology
HyperlinkGene Summary
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM
Other Designations
aurora-1|aurora-B|serine/threonine kinase 12
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Interactome
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Disease
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Publication Reference
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Cell cycle-dependent regulation of the human aurora B promoter.
Kimura M, Uchida C, Takano Y, Kitagawa M, Okano Y.
Biochemical and Biophysical Research Communications 2004 Apr; 316(3):930.
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Correcting improper chromosome-spindle attachments during cell division.
Lampson MA, Renduchitala K, Khodjakov A, Kapoor TM.
Nature Cell Biology 2004 Mar; 6(3):232.
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Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis.
Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, Furukawa K, Takahashi T, Izawa I, Inagaki M.
The Journal of Biological Chemistry 2004 Jan; 279(13):12997.
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Cell cycle-dependent regulation of the human aurora B promoter.
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