NF2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells untreated or treated with IFN-alpha (100 ng/mL, 15 min) using NF2 polyclonal antibody (Cat # PAB26790).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using NF2 polyclonal antibody (Cat # PAB26790).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NF2.
Immunogen
A synthetic peptide corresponding to residues surrounding S518 of human NF2.
Sequence
R-L-Sp-M-E
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Purification
Affinity chromatography
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from 293 cells untreated or treated with IFN-alpha (100 ng/mL, 15 min) using NF2 polyclonal antibody (Cat # PAB26790).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using NF2 polyclonal antibody (Cat # PAB26790). -
Gene Info — NF2
Entrez GeneID
4771Protein Accession#
P35240Gene Name
NF2
Gene Alias
ACN, BANF, SCH
Gene Description
neurofibromin 2 (merlin)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq
Other Designations
merlin|moesin-ezrin-radixin like|moesin-ezrin-radizin-like protein|neurofibromin 2|neurofibromin 2 (bilateral acoustic neuroma)|schwannomerlin|schwannomin
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Interactome
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Disease
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