ABCC1 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with ABCC1 polyclonal antibody (Cat # PAB21085) shows strong cytoplasmic positivity in a subset of cells in glomeruli.
Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with ABCC1 polyclonal antibody (Cat # PAB21085) at 1-4 ug/mL dilution shows positivity in plasma membrane.
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant ABCC1.
Immunogen
Recombinant protein corresponding to amino acids of human ABCC1.
Sequence
LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWD
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (1:50-1:200)
Immunofluorescence (1-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human kidney with ABCC1 polyclonal antibody (Cat # PAB21085) shows strong cytoplasmic positivity in a subset of cells in glomeruli.Immunofluorescence
Immunofluorescent staining of human cell line U-2 OS with ABCC1 polyclonal antibody (Cat # PAB21085) at 1-4 ug/mL dilution shows positivity in plasma membrane. -
Gene Info — ABCC1
Entrez GeneID
4363Protein Accession#
P33527Gene Name
ABCC1
Gene Alias
ABC29, ABCC, DKFZp686N04233, DKFZp781G125, GS-X, MRP, MRP1
Gene Description
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
Omim ID
158343Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternative splicing by exon deletion results in several splice variants but maintains the original open reading frame in all forms. [provided by RefSeq
Other Designations
ATP-binding cassette, sub-family C, member 1|LTC4 transporter|OTTHUMP00000045904|leukotriene C(4) transporter|multidrug resistance protein|multiple drug resistance protein 1|multiple drug resistance-associated protein
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Interactome
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Pathway
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Disease
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