CDK7 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from Raw 264.7 cells, treated with Calyculin A (50 ng/mL, 30 mins), using CDK7 polyclonal antibody (Cat # PAB18323).
Peptide "+" means "peptide blocking".
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CDK7 polyclonal antibody (Cat # PAB18323).
Peptide "+" means "peptide blocking".
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CDK7.
Immunogen
A synthetic peptide corresponding to residues surrounding T170 of human CDK7.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
This antibody is specific to CDK7.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from Raw 264.7 cells, treated with Calyculin A (50 ng/mL, 30 mins), using CDK7 polyclonal antibody (Cat # PAB18323).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CDK7 polyclonal antibody (Cat # PAB18323).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CDK7
Entrez GeneID
1022Protein Accession#
P50613Gene Name
CDK7
Gene Alias
CAK1, CDKN7, MO15, STK1, p39MO15
Gene Description
cyclin-dependent kinase 7
Omim ID
601955Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq
Other Designations
39 KDa protein kinase|Cdk-activating kinase|cell division protein kinase 7|cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)|homolog of Xenopus MO15 Cdk-activating kinase|kinase subunit of CAK|serine/threonine kinase stk1|ser
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Interactome
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Pathway
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Disease
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Publication Reference
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In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation.
Ito S, Takeyama K, Yamamoto A, Sawatsubashi S, Shirode Y, Kouzmenko A, Tabata T, Kato S.
Genes to Cells: Devoted to Molecular & Cellular Mechanisms 2004 Oct; 9(10):983.
Application：IP, Human, HEK 293T cells.
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Meiotic expression of the cyclin H/Cdk7 complex in male germ cells of the mouse.
Kim JM, McGaughy JT, Bogle RK, Ravnik SE.
Biology of Reproduction 2001 May; 64(5):1400.
Application：IHC-P, IP, WB, Mouse, Mouse testes.
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In vivo potentiation of human oestrogen receptor alpha by Cdk7-mediated phosphorylation.
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