Western blot analysis with IL18 polyclonal antibody (Cat # PAB18297). 1 : Recombinant human IL18 protein 10 ng. 2 : Recombinant human IL18 protein 5 ng. 3 : Recombinant human IL18 protein 2.5 ng. 4 : Raji whole cell lysate.
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq