CEBPB polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CEBPB.
Immunogen
A synthetic peptide corresponding to human CEBPB.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to CEBPB.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:300-1:1000)
Immunohistochemistry (1:50-1:100)
ELISA (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NIH/3T3 cells, using CEBPB polyclonal antibody (Cat # PAB18114).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using CEBPB polyclonal antibody (Cat # PAB18114).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — CEBPB
Entrez GeneID
1051Protein Accession#
P17676Gene Name
CEBPB
Gene Alias
C/EBP-beta, CRP2, IL6DBP, LAP, MGC32080, NF-IL6, TCF5
Gene Description
CCAAT/enhancer binding protein (C/EBP), beta
Omim ID
189965Gene Ontology
HyperlinkGene Summary
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq
Other Designations
CCAAT/enhancer binding protein beta|interleukin 6-dependent DNA-binding protein|liver-enriched transcriptional activator protein|nuclear factor of interleukin 6|transcription factor 5
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Interactome
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Disease
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Publication Reference
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CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.
Zhu S, Yoon K, Sterneck E, Johnson PF, Smart RC.
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan; 99(1):207.
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Critical role of C/EBPdelta and C/EBPbeta factors in the stimulation of the cyclooxygenase-2 gene transcription by interleukin-1beta in articular chondrocytes.
Thomas B, Berenbaum F, Humbert L, Bian H, Bereziat G, Crofford L, Olivier JL.
European Journal of Biochemistry 2000 Dec; 267(23):6798.
Application:GSA, Rabbit, Chondrocyte.
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Regulation of Gadd45gamma expression by C/EBP.
Jung N, Yi YW, Kim D, Shong M, Hong SS, Lee HS, Bae I.
European Journal of Biochemistry 2000 Oct; 267(20):6180.
Application:Func, WB-Ce, Mouse, M1 myeloid cells, NIH/3T3 cells.
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CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.
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