ILK (phospho T173) polyclonal antibody
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More Files
- More Functions
Dot Blot (Peptide)
Dot blot analysis of ILK (phospho T173) polyclonal antibody (Cat # PAB1640) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of ILK.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding T173 of human ILK.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein A purification
Recommend Usage
Dot Blot (1:500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Dot Blot (Peptide)
Dot blot analysis of ILK (phospho T173) polyclonal antibody (Cat # PAB1640) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. -
Gene Info — ILK
Entrez GeneID
3611Protein Accession#
Q13418;NP_004508Gene Name
ILK
Gene Alias
DKFZp686F1765, P59
Gene Description
integrin-linked kinase
Omim ID
602366Gene Ontology
HyperlinkGene Summary
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Publication Reference
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Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.
Li Y, Yang J, Dai C, Wu C, Liu Y.
The Journal of Clinical Investigation 2003 Aug; 112(4):503.
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Characterisation of integrin-linked kinase signalling in sporadic human colon cancer.
Marotta A, Parhar K, Owen D, Dedhar S, Salh B.
British Journal of Cancer 2003 Jun; 88(11):1755.
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Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.
Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S.
The Journal of Biological Chemistry 2003 Apr; 278(25):22374.
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Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.
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