BIRC3 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot of HeLa whole cell lysate wiht BIRC3 polyclonal antibody (Cat # PAB15528).
Immunohistochemistry
Immunohistochemical analysis of human adenocarcinoma cells and adjacent glands using BIRC3 polyclonal antibody (Cat # PAB15528).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIRC3.
Immunogen
A synthetic peptide corresponding to amino acids 100-200 of human BIRC3.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is useful for Western blot analysis where a band can be seen at ~64 KDa.
Form
Liquid
Recommend Usage
Immunocytochemistry (1:100)
Immunofluorescence (1:100)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:800-1:3200)
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot of HeLa whole cell lysate wiht BIRC3 polyclonal antibody (Cat # PAB15528).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
Immunohistochemical analysis of human adenocarcinoma cells and adjacent glands using BIRC3 polyclonal antibody (Cat # PAB15528).Immunocytochemistry
Immunofluorescence
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Gene Info — BIRC3
Entrez GeneID
330Protein Accession#
Q13489Gene Name
BIRC3
Gene Alias
AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49
Gene Description
baculoviral IAP repeat-containing 3
Omim ID
601721Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq
Other Designations
TNFR2-TRAF signaling complex protein|apoptosis inhibitor 2|baculoviral IAP repeat-containing protein 3|inhibitor of apoptosis protein 1|mammalian IAP homolog C
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Interactome
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Pathway
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Disease
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Publication Reference
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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
Bertrand MJ, Doiron K, Labbe K, Korneluk RG, Barker PA, Saleh M.
Immunity 2009 May; 30(6):789.
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Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survival.
Conte D, Holcik M, Lefebvre CA, Lacasse E, Picketts DJ, Wright KE, Korneluk RG.
Molecular and Cellular Biology 2006 Jan; 26(2):699.
Application：WB-Ti, Mouse, Lung.
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Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
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