Amyloid-beta polyclonal antibody
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More Files
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Dot Blot (Peptide)
Dot blot of Beta amyloid polyclonal antibody (Cat # PAB13587) at a 1 : 1000 dilution. The antibody can detect Beta amyloid (1-42), Beta amyloid (1-28), Beta amyloid (1-20) and Beta amyloid (1-17).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Beta amyloid.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to amino acids 1-42 of human Amyloid-beta.
Sequence
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Host
Rabbit
Reactivity
Human
Specificity
This antibody can detect Abeta (1-42), Abeta (1-28) Abeta (1-20) and Abeta (1-17). This product exhibits a low reactivity to monomeric Abeta (1-42).
Form
Lyophilized
Recommend Usage
ELISA (1:3000)
Dot Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from serum
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterile water, store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Enzyme-linked Immunoabsorbent Assay
Dot Blot (Peptide)
Dot blot of Beta amyloid polyclonal antibody (Cat # PAB13587) at a 1 : 1000 dilution. The antibody can detect Beta amyloid (1-42), Beta amyloid (1-28), Beta amyloid (1-20) and Beta amyloid (1-17). -
Gene Info — APP
Entrez GeneID
351Protein Accession#
P05067Gene Name
APP
Gene Alias
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gene Description
amyloid beta (A4) precursor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A4 amyloid protein|amyloid beta A4 protein|amyloid-beta protein|beta-amyloid peptide|cerebral vascular amyloid peptide|peptidase nexin-II|protease nexin-II
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Interactome
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Disease
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