AIFM1 polyclonal antibody
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More Files
- More Functions
Western Blot
Western blot analysis of AIFM1 in K-562 cell lysate (A), mouse (B), and rat (C) liver tissue lysates with AIFM1 polyclonal antibody (Cat # PAB13405) at 1 ug/mL .
Immunocytochemistry
Immunocytochemistry of AIFM1 in K-562 cells with AIFM1 polyclonal antibody (Cat # PAB13405) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AIFM1.
Immunogen
A synthetic peptide corresponding to amino acids 593-606 of human AIFM1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This sequence is identical to those of mouse and rat AIF.
Form
Liquid
Recommend Usage
Western Blot (0.25-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of AIFM1 in K-562 cell lysate (A), mouse (B), and rat (C) liver tissue lysates with AIFM1 polyclonal antibody (Cat # PAB13405) at 1 ug/mL .Immunocytochemistry
Immunocytochemistry of AIFM1 in K-562 cells with AIFM1 polyclonal antibody (Cat # PAB13405) at 5 ug/mL . -
Gene Info — AIFM1
Entrez GeneID
9131Protein Accession#
O95831Gene Name
AIFM1
Gene Alias
AIF, MGC111425, PDCD8
Gene Description
apoptosis-inducing factor, mitochondrion-associated, 1
Omim ID
300169Gene Ontology
HyperlinkGene Summary
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000024007|OTTHUMP00000024008|OTTHUMP00000024009|programmed cell death 8|programmed cell death 8 (apoptosis-inducing factor)|striatal apoptosis-inducing factor
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Interactome
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Pathway
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Disease
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Publication Reference
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Condensed matter in cell death.
Zamzami N, Kroemer G.
Nature 1999 Sep; 401(6749):127.
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Molecular characterization of mitochondrial apoptosis-inducing factor.
Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G.
Nature 1999 Feb; 397(6718):441.
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Condensed matter in cell death.
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