APH1A polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of APH1A in human brain tissue lysate with APH1A polyclonal antibody (Cat # PAB13238) at (A) 0.5 and (B) 1 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of APH1A in human brain tissue with APH1A polyclonal antibody (Cat # PAB13238) at 5 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of APH1A.
Immunogen
A synthetic peptide corresponding to internal region 18 amino acids of human APH1A.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of APH1A in human brain tissue lysate with APH1A polyclonal antibody (Cat # PAB13238) at (A) 0.5 and (B) 1 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of APH1A in human brain tissue with APH1A polyclonal antibody (Cat # PAB13238) at 5 ug/mL . -
Gene Info — APH1A
Entrez GeneID
51107Protein Accession#
AAH08732Gene Name
APH1A
Gene Alias
6530402N02Rik, APH-1A, CGI-78
Gene Description
anterior pharynx defective 1 homolog A (C. elegans)
Omim ID
607629Gene Ontology
HyperlinkGene Summary
APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM
Other Designations
OTTHUMP00000014528|OTTHUMP00000014529|anterior pharynx defective 1 homolog A
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Interactome
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Pathway
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Disease
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Publication Reference
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APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.
Ma G, Li T, Price DL, Wong PC.
Journal of Neuroscience 2005 Jan; 25(1):192.
Application：WB, Mouse, Mouse fibroblasts.
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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.
Journal of Neuroscience Research 2004 Aug; 77(3):309.
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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.
Goutte C, Tsunozaki M, Hale VA, Priess JR.
PNAS 2002 Jan; 99(2):775.
Application：IEM, C. elegans, C. elegans embryos.
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APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development.
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