AOF2 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of AOF2 in P815 cell lysate with AOF2 polyclonal antibody (Cat # PAB13190) at (A) 1 and (B) 2 ug/mL .
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of AOF2 in human small intestine tissue with AOF2 polyclonal antibody (Cat # PAB13190) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AOF2.
Immunogen
A synthetic peptide corresponding to internal region 16 amino acids of human AOF2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of AOF2 in P815 cell lysate with AOF2 polyclonal antibody (Cat # PAB13190) at (A) 1 and (B) 2 ug/mL .Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of AOF2 in human small intestine tissue with AOF2 polyclonal antibody (Cat # PAB13190) at 2 ug/mL . -
Gene Info — AOF2
Entrez GeneID
23028Protein Accession#
NP_001009999Gene Name
AOF2
Gene Alias
BHC110, KDM1, KIAA0601, LSD1
Gene Description
amine oxidase (flavin containing) domain 2
Omim ID
609132Gene Ontology
HyperlinkGene Summary
This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq
Other Designations
BRAF35-HDAC complex protein BHC110|FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit|lysine (K)-specific demethylase 1|lysine-specific histone demethylase 1
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Interactome
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Publication Reference
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Shi Y, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y.
Cell 2004 Dec; 119(7):941.
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ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation.
Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo A, Croce CM, Canaani E.
Molecular Cell 2002 Nov; 10(5):1119.
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Histone methylation in transcriptional control.
Kouzarides T.
Current Opinion in Genetics & Development 2002 Apr; 12(2):198.
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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
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