CXCR4 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western blot analysis of CXCR4 in (A) human spleen and (B) human thymus tissue lysate with CXCR4 polyclonal antibody (Cat # PAB13024) at 10 ug/mL .
Immunocytochemistry
Immunocytochemistry of CXCR4 in HeLa cells with CXCR4 polyclonal antibody (Cat # PAB13024) at 2 ug/mL .
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CXCR4.
Immunogen
A synthetic peptide corresponding to N-terminus 9 amino acids of human CXCR4.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of CXCR4 in (A) human spleen and (B) human thymus tissue lysate with CXCR4 polyclonal antibody (Cat # PAB13024) at 10 ug/mL .Immunocytochemistry
Immunocytochemistry of CXCR4 in HeLa cells with CXCR4 polyclonal antibody (Cat # PAB13024) at 2 ug/mL . -
Gene Info — CXCR4
Entrez GeneID
7852Protein Accession#
NP_001008540Gene Name
CXCR4
Gene Alias
CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
Gene Description
chemokine (C-X-C motif) receptor 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
Other Designations
C-X-C chemokine receptor type 4|CD184 antigen|chemokine (C-X-C motif), receptor 4 (fusin)|chemokine receptor 4|fusin|leukocyte-derived seven-transmembrane-domain receptor|lipopolysaccharide-associated protein 3|neuropeptide Y receptor Y3|seven transmembra
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Interactome
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Pathway
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Disease
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Publication Reference
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How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
Dimitrov DS.
Cell 1997 Dec; 91(6):721.
Application：Flow Cyt, Human, Mouse, T cells.
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A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains.
Berson JF, Long D, Doranz BJ, Rucker J, Jirik FR, Doms RW.
Journal of Virology 1996 Sep; 70(9):6288.
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A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW.
Cell 1996 Jun; 85(7):1149.
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How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity.
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