BIRC2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BIRC2.
Immunogen
A synthetic peptide corresponding to C-terminus 14 amino acids of human BIRC2.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
c-IAP antibody detects both c-IAP1 and c-IAP2.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of BIRC2 in human lung tissue lysate with BIRC2 polyclonal antibody (Cat # PAB12922) at 1 (lane A), 2 (lane B), and 4 (lane C) ug/mL , respectively.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry of BIRC2 in human lung with BIRC2 polyclonal antibody (Cat # PAB12922) at 10 ug/mL . -
Gene Info — BIRC2
Entrez GeneID
329Protein Accession#
NP_001157Gene Name
BIRC2
Gene Alias
API1, HIAP2, Hiap-2, MIHB, RNF48, cIAP1
Gene Description
baculoviral IAP repeat-containing 2
Omim ID
601712Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. [provided by RefSeq
Other Designations
NFR2-TRAF signalling complex protein|apoptosis inhibitor 1|baculoviral IAP repeat-containing protein 2
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Interactome
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Pathway
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Disease
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Publication Reference
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TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
Li X, Yang Y, Ashwell JD.
Nature 2002 Mar; 416(6878):345.
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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases.
Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC.
The EMBO Journal 1998 Apr; 17(8):2215.
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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins.
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV.
Cell 1995 Dec; 83(7):1243.
Application:WB-Ti, Human, Mouse, Human tissues, Mouse tissues.
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TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
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