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Last updated: 2014/4/21
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BIOtech
BULK-new

ABL1 polyclonal antibody

  • Catalog # : PAB12499
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of ABL1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 700-800 of human ABL1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Western Blot (2 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In Tris-citrate/phosphate buffer, pH 7.0-8.0 (0.1% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of ABL1 in K-562 whole cell lysate using ABL1 polyclonal antibody (Cat # PAB12499).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
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  • Gene Information
  • Entrez GeneID:
  • 25
  • Gene Name:
  • ABL1
  • Gene Alias:
  • ABL,JTK7,bcr/abl,c-ABL,p150,v-abl
  • Gene Description:
  • c-abl oncogene 1, receptor tyrosine kinase
  • Gene Summary:
  • The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq
  • Other Designations:
  • Abelson murine leukemia viral (v-abl) oncogene homolog 1,OTTHUMP00000022375,OTTHUMP00000022376,bcr/c-abl oncogene protein,proto-oncogene tyrosine-protein kinase ABL1,v-abl Abelson murine leukemia viral oncogene homolog 1
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