CHRNA1 polyclonal antibody
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More Files
- More Functions
Western Blot (Tissue lysate)
Western Blot analysis of CHRNA1 expression from rat skeletal muscle lyate with CHRNA1 polyclonal antibody (Cat # PAB12331).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of CHRNA1 on formalin fixed, paraffin embedded rat brain with CHRNA1 polyclonal antibody (Cat # PAB12331).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CHRNA1.
Immunogen
A synthetic peptide corresponding to amino acids at N-terminus of human CHRNA1.
Host
Rabbit
Theoretical MW (kDa)
54.5
Reactivity
Human, Mouse, Rat
Specificity
Identical to the related rat and mouse sequence.
Form
Lyophilized
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot (0.75 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.9 mg NaCl, 0.2 mg Na2HPO4 (5 mg BSA, 0.05 mg sodium azide, 0.05 mg Thimerosal)
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 200 uL of deionized water and concentration will be 500 ug/mL, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide and thimerosal: POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western Blot analysis of CHRNA1 expression from rat skeletal muscle lyate with CHRNA1 polyclonal antibody (Cat # PAB12331).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of CHRNA1 on formalin fixed, paraffin embedded rat brain with CHRNA1 polyclonal antibody (Cat # PAB12331). -
Gene Info — CHRNA1
Entrez GeneID
1134Gene Name
CHRNA1
Gene Alias
ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS
Gene Description
cholinergic receptor, nicotinic, alpha 1 (muscle)
Gene Ontology
HyperlinkGene Summary
The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)|nicotinic acetylcholine receptor alpha subunit|nicotinic cholinergic receptor alpha 1
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Interactome
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Disease
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Publication Reference
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Stability of motor endplates is greater in the biceps than in the interossei in a rat model of obstetric brachial plexus palsy.
Bo Li, Liang Chen, Yu-Dong Gu.
Neural Regeneration Research 2020 Sep; 15(9):1678.
Application：WB-Ti, Rat, Rat biceps, Rat bilateral interossei.
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An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus.
Giraud M, Taubert R, Vandiedonck C, Ke X, Lévi-Strauss M, Pagani F, Baralle FE, Eymard B, Tranchant C, Gajdos P, Vincent A, Willcox N, Beeson D, Kyewski B, Garchon HJ.
Nature 2007 Aug; 448(7156):934.
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Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor.
Noda M, Furutani Y, Takahashi H, Toyosato M, Tanabe T, Shimizu S, Kikyotani S, Kayano T, Hirose T, Inayama S, et al..
Nature 1983 Oct; 305(5937):818.
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Stability of motor endplates is greater in the biceps than in the interossei in a rat model of obstetric brachial plexus palsy.
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