MET polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of MET.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y1003 of human MET.
Sequence
VDYRA
Host
Rabbit
Theoretical MW (kDa)
156
Reactivity
Human, Mouse, Rat
Specificity
Met (Ab-1003) Antibody detects endogenous levels of total Met protein.
Form
Liquid
Purification
Immunoaffinity purification
Concentration
1 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MET polyclonal antibody (Cat # PAB12251). -
Gene Info — MET
Entrez GeneID
4233Protein Accession#
P08581Gene Name
MET
Gene Alias
AUTS9, HGFR, RCCP2, c-Met
Gene Description
met proto-oncogene (hepatocyte growth factor receptor)
Gene Ontology
HyperlinkGene Summary
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
HGF receptor|OTTHUMP00000069168|SF receptor|met proto-oncogene|met proto-oncogene tyrosine kinase|oncogene MET|scatter factor receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Tyrosine kinase inhibitors: from rational design to clinical trials.
Traxler P, Bold G, Buchdunger E, Caravatti G, Furet P, Manley P, O'Reilly T, Wood J, Zimmermann J.
Medicinal Research Reviews 2001 Nov; 21(6):499.
Application:KA, WB, Human, Cancer, Mammalian cells.
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Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses.
Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W.
The Journal of Cell Biology 2000 Jun; 149(7):1419.
Application:WB-Tr, Human, HEK 293 cells.
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The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells.
Weidner KM, Sachs M, Birchmeier W.
The Journal of Cell Biology 1993 Apr; 121(1):145.
Application:IP, Dog, MDCK cells.
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Tyrosine kinase inhibitors: from rational design to clinical trials.
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