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Last updated: 2014/4/21
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BIOtech
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CBL (phospho Y700) polyclonal antibody

  • Catalog # : PAB12198
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic phosphopeptide of CBL.
  • Immunogen:
  • Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y700 of human CBL.
  • Sequence:
  • TEYpMT
  • Host:
  • Rabbit
  • Theoretical MW (kDa):
  • 120
  • Reactivity:
  • Human
  • Specificity:
  • c-Cbl (phospho-Tyr700) Antibody detects endogenous levels of c-Cbl only when phosphorylated at tyrosine 700.
  • Form:
  • Liquid
  • Purification:
  • Immunoaffinity purification
  • Concentration:
  • 1 mg/mL
  • Quality Control Testing:
  • Antibody Reactive Against Synthetic Peptide.
  • Recommend Usage:
  • Immunohistochemistry (1:50-1:100)
    Immunofluorescence (1:100-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CBL (phospho Y700) polyclonal antibody (Cat # PAB12198).
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence staining of methanol-fixed HeLa cells using CBL (phospho Y700) polyclonal antibody (Cat # PAB12198, red).
  • Application Image
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 867
  • Gene Name:
  • CBL
  • Gene Alias:
  • C-CBL,CBL2,RNF55
  • Gene Description:
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • Gene Summary:
  • The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
  • Other Designations:
  • oncogene CBL2
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