STIM1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of STIM1.
Immunogen
A synthetic peptide corresponding to amino acids 600-685 of human STIM1.
Host
Rabbit
Reactivity
Bovine, Dog, Human, Mouse, Pig, Rat
Form
Liquid
Recommend Usage
Immunocytochemistry (1:50-1:200)
Immunofluorescence (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of STIM1 in HeLa whole cell extract with STIM1 polyclonal antibody (Cat # PAB12017).Immunocytochemistry
Immunofluorescence
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Gene Info — STIM1
Entrez GeneID
6786Protein Accession#
Q13586Gene Name
STIM1
Gene Alias
D11S4896E, GOK
Gene Description
stromal interaction molecule 1
Omim ID
605921Gene Ontology
HyperlinkGene Summary
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene
Other Designations
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Interactome
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Publication Reference
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Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells.
Bittremieux M, La Rovere RM, Schuermans M, Luyten T, Mikoshiba K, Vangheluwe P, Parys JB, Bultynck G.
Cell Death Discovery 2018 Nov; 4:101.
Application:WB, Human, SU-DHL-4 cells.
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Extracellular and ER-stored Ca2+ contribute to BIRD-2-induced cell death in diffuse large B-cell lymphoma cells.
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