TARDBP polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
TARDBP polyclonal antibody (Cat # PAB11464) (0.3 ug/mL) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of TARDBP.
Immunogen
A synthetic peptide corresponding to human TARDBP.
Sequence
C-HISNAEPKHNSNRQ
Host
Goat
Theoretical MW (kDa)
44.7
Reactivity
Human, Mouse
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
TARDBP polyclonal antibody (Cat # PAB11464) (0.3 ug/mL) staining of Jurkat lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TARDBP
Entrez GeneID
23435Protein Accession#
NP_031401.1Gene Name
TARDBP
Gene Alias
ALS10, TDP-43
Gene Description
TAR DNA binding protein
Omim ID
605078Gene Ontology
HyperlinkGene Summary
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq
Other Designations
OTTHUMP00000002171|TAR DNA-binding protein-43
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Interactome
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Disease
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Publication Reference
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Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
Liu YJ, Ju TC, Chen HM, Jang YS, Lee LM, Lai HL, Tai HC, Fang JM, Lin YL, Tu PH, Chern Y.
Human Molecular Genetics 2015 Feb; 24(3):787.
Application：IF, WB-Ce, WB-Tr, Human, Mouse, Spinal cord, muscle, NSC34 cells.
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Skin disruption is associated with indomethacin-induced small intestinal injury in mice.
Yokoyama S, Hiramoto K, Koyama M, Ooi K.
Experimental Dermatology 2014 Sep; 23(9):659.
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Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43.
Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D, Petrucelli L.
The Journal of Neuroscience 2007 Sep; 27(39):10530.
Application：IF, IHC, WB-Ce, WB-Ti, Human, HeLa, H4 cells, Brain.
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Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
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