Pro - BDNF staining within the rat spinal cord dorsal horn. Normal cryostat sections of adult rat cord were stained with recombinant human anti - proBDNF (Cat # PAB0745) and detected with HRP labelled anti - rabbit antibody. Dilution 1 : 2000 in Human mouse and rat. (Image courtesy of Dr Xin-fu Zhou).
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq